Names | |
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IUPAC name | |
Other names N,N-Dimethylglycine | |
Identifiers | |
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3DMet | |
1700261 | |
ChEBI | |
ChemSpider |
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DrugBank | |
ECHA InfoCard | 100.012.971 |
EC Number |
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82215 | |
KEGG |
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MeSH | dimethylglycine |
RTECS number | |
CompTox Dashboard(EPA) | |
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Properties | |
C4H9NO2 | |
Molar mass | 103.121 g·mol−1 |
Appearance | White crystals |
Odor | Odourless |
Density | 1.069 g/mL |
Melting point | 178 to 182 °C (352 to 360 °F; 451 to 455 K) |
Boiling point | 175.2 °C (347.4 °F; 448.3 K) |
Hazards | |
GHS pictograms | |
GHS Signal word | Warning |
H302 | |
Lethal dose or concentration (LD, LC): | |
>650 mg kg−1(oral, rat) | |
Related compounds | |
Related alkanoic acids | |
Dimethylacetamide | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
verify (what is ?) | |
Infobox references |
See the player’s D&D basic rules or the Player’s Handbook for descriptions of the different alignments. The alignment specified in a monster’s stat block is the default. Feel free to depart from it and change a monster’s alignment to suit the needs of your campaign. Nov 18, 2019 Again, just because you can extract a DMG file in Windows, or even convert a DMG to a Windows-readable format, doesn't always mean that the contents of the DMG file will suddenly become compatible with Windows. The only way to use a Mac program or a Mac video game in Windows is to download the Windows-equivalent version.
Dimethylglycine (DMG) is a derivative of the amino acidglycine with the structural formula (CH3)2NCH2COOH. It can be found in beans and liver. It can be formed from trimethylglycine upon the loss of one of its methyl groups. It is also a byproduct of the metabolism of choline.
When DMG was first discovered, it was referred to as Vitamin B16, but, unlike true B vitamins, deficiency of DMG in the diet does not lead to any ill-effects and it is synthesized by the human body in the citric acid (or Krebs) cycle meaning it does not meet the definition of a vitamin.
Uses[edit]
Roll20 brings pen-and-paper gameplay to your browser with features that save time and enhance your favorite parts of tabletop games. DM here with a nagging question re: the swashbuckling rogue in my party. If a player misses with the primary attack can the bonus action secondary attack still add sneak attack damage if it hits? On the one hand (no pun intended) if the action and bonus are considered to essentially happen within seconds of each other than that makes sense to me.
Dnd Dmg Vs Secondary Dmg 3
Dimethylglycine has been suggested for use as an athletic performance enhancer, immunostimulant, and a treatment for autism, epilepsy, or mitochondrial disease.[2] There is no evidence that dimethylglycine is effective for treating mitochondrial disease.[3] Published studies on the subject have shown little to no difference between DMG treatment and placebo in autism spectrum disorders.[4][5]
Biological activity[edit]
![Dnd Dnd](/uploads/1/2/5/3/125383172/641003478.jpg)
Dimethylglycine has been found to act as an agonist of the glycine site of the NMDA receptor.[6]
Preparation[edit]
This compound is commercially available as the free form amino acid, and as the hydrochloride salt [2491-06-7 ]. DMG may be prepared by the alkylation of glycine via the Eschweiler–Clarke reaction. In this reaction, glycine is treated with aqueous formaldehyde in formic acid that serves as both solvent and reductant. Hydrochloric acid is added thereafter to give the hydrochloride salt. The free amino acid may have been obtained by neutralization of the acid salt, which has been performed with silver oxide.[7]
- H2NCH2COOH + 2 CH2O + 2 HCOOH → (CH3)2NCH2COOH + 2 CO2 + 2 H2O
References[edit]
- ^'dimethylglycine - Compound Summary'. PubChem Compound. USA: National Center for Biotechnology Information. 16 September 2004. Identification. Retrieved 24 April 2012.
- ^'Dimethylglycine'. About Herbs, Botanicals & Other Products. Memorial Sloan–Kettering Cancer Center. December 8, 2009.
- ^Pfeffer, Gerald; Majamaa, Kari; Turnbull, Douglass M.; Thorburn, David; Chinnery, Patrick F. (2012-04-18). 'Treatment for mitochondrial disorders'. The Cochrane Database of Systematic Reviews (4): CD004426. doi:10.1002/14651858.CD004426.pub3. ISSN1469-493X. PMID22513923.
- ^Bolman WM, Richmond JA (June 1999). 'A double-blind, placebo-controlled, crossover pilot trial of low-dose dimethylglycine in patients with autistic disorder'. Journal of Autism and Developmental Disorders. 29 (3): 191–4. doi:10.1023/A:1023023820671. PMID10425581.
- ^Kern JK, Miller VS, Cauller PL, Kendall PR, Mehta PJ, Dodd M (March 2001). 'Effectiveness of N,N-dimethylglycine in autism and pervasive developmental disorder'. Journal of Child Neurology. 16 (3): 169–73. doi:10.1177/088307380101600303. PMID11305684.
- ^Lin, Jen-Cheng; Chan, Ming-Huan; Lee, Mei-Yi; Chen, Yi-Chyan; Chen, Hwei-Hsien (2016). 'N,N-dimethylglycine differentially modulates psychotomimetic and antidepressant-like effects of ketamine in mice'. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 71: 7–13. doi:10.1016/j.pnpbp.2016.06.002. ISSN0278-5846. PMID27296677.
- ^Clarke, H. T.; Gillespie, H. B.; Weisshaus, S. Z. (1933). 'The Action of Formaldehyde on Amines and Amino Acids'. Journal of the American Chemical Society. 55 (11): 4571. doi:10.1021/ja01338a041.
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